TRADE NAME IN INDIA - UDEZIRE
Erectile dysfunction (ED) is an inability to achieve or sustain an erection suitablefor sexual intercourse. Sexologists say at least 10% men in India may have to use these drugs at some point. Studies have shown that 40% of men up to the age of 40 years have ED andit goesup 70% by 60 years.
The commonly prescribed drugs for the disorder in India are sildenafil(Viagra) and tadalafil,which belong to a category called phosphodiesterasetype5 drugs. Now, Zydus, a pharmaceutical company, has got exclusive permission to sell udenafil.
Mechanism Of Action
Udenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degeneration of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is produced by increased penile blood flow caused by the relaxation of penile arteries and corpus cavernosal smooth muscle. This reaction is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by udenafil reinforces erection by increasing the amount of cGMP.Udenafil Dosing and Administration
Pills taken by mouth, with or without food, for 30 minutes before the alleged sexual activity.
Recommended dose – 100 mg. If necessary, taking into account individual performance and portability, the dose may be increased to 200 mg. The maximum recommended frequency of application – 1 times / day.
Side effects of Udenafil
Palpitations, prolonged erections, flushing, dizziness eye pain, increased lacrimation, nasal congestion, headache.
Cautions
Sexual activity is a potential risk for patients with cardiovascular disease, hypertension, so treatment of sexual dysfunctions, should not hold for men with diseases, when sexual activity is not recommended.
Also, there is no clinical data on the use of Udenafil for patients older than 71 y.o.
Advantages
- rapid and predictable onset of action
- provides necessary to erection hardness
- increases the axial load on the penis
- reduces the time of the refractory period (time after ejaculation until the next erection)
- optimal duration of up to 24 hours
- high safety profile in the class of PDE-5 inhibitors
- Drinking alcohol and fatty food does not affect the action of Udenafil
The new drug will be priced at 575 per tablet, a little lesser than Viagra.
