There are many ways in which a person can lose weight. Results may vary depending on diet and physical activity.
When it comes to safer medicines to tackle obesity one name stands out among various pharmacological agents available
"ORLISTAT"The original product introduced was XENICAL
in India this drug is sold in various names. Here is the list of them....
COBESE, JM-SLIM, LIPOCUT, LIPOPHAGE, OBELIT, OBETY, OBFREE, OLISAT, ORLE, ORLEAN, ORLICA, ORLID, ORLIFE, ORLIMAC, ORLISS, REESHAPE, TROYSLIM, VYFAT, ZEROFAT
What is this drug??
Orlistat is a drug designed to treat obesity. It isalso known as tetrahydrolipstatin. It is marketed as a prescription under the trade name Xenical by Roche. It acts by reducing the fat absorption from our diet and reducing the caloric intake.
Orlistat is the derivative of lipstatin, a potent inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. The effectiveness of orlistat in promoting weight loss is definite, orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms. Orlistat also modestly reduces blood pressure, and appears to prevent the onset of type 2 diabetes, whether due to weight loss itself or to other effects.
Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and are excreted undigested instead. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces.
Side effects-
Steatorrhea (oily, loose stools with excessive flatus)
fecal incontinence and frequent or urgent bowel movements.
Precautions
Absorption of fat-soluble vitamins and other fat-soluble nutrients is hampered. A multivitamin tablet containing vitamins A, D, E, K, and beta-carotene should be taken once a day, at bedtime, when using orlistat.
Possible interactions with other drugs-
Reduces plasma levels of cyclosporine
impairs absorption of Amiodarone
Orlistat better avoided in -
Orlistat is a drug designed to treat obesity. It isalso known as tetrahydrolipstatin. It is marketed as a prescription under the trade name Xenical by Roche. It acts by reducing the fat absorption from our diet and reducing the caloric intake.
Orlistat is the derivative of lipstatin, a potent inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. The effectiveness of orlistat in promoting weight loss is definite, orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms. Orlistat also modestly reduces blood pressure, and appears to prevent the onset of type 2 diabetes, whether due to weight loss itself or to other effects.
Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and are excreted undigested instead. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces.
Side effects-
Steatorrhea (oily, loose stools with excessive flatus)
fecal incontinence and frequent or urgent bowel movements.
Precautions
Absorption of fat-soluble vitamins and other fat-soluble nutrients is hampered. A multivitamin tablet containing vitamins A, D, E, K, and beta-carotene should be taken once a day, at bedtime, when using orlistat.
Possible interactions with other drugs-
Reduces plasma levels of cyclosporine
impairs absorption of Amiodarone
Orlistat better avoided in -
- Malabsorption
- Hypersensitivity to orlistat
- Reduced gallbladder function
- Pregnancy and breastfeeding
