Etiology
Exact etiology is not clear as of now. it has been suggested that some patients may develop Flatbush diabetes as they are extremely sensitive to transient damage to Beta cells by Glucotoxicity & Lipotoxicity. when this condition is reversed with diet , oral hypoglycemic agents or Insulin the beta cells are able to recover.
Why is the knowledge about Flatbush Diabetes important??
There is a lot we do not know about flatbush diabetes but the more we are aware that such a form of diabetes exists ,the more our physicians will be apt to spot patients who have it, and the more patients are correctly Diagnosed, the better their treatment will be!!
Characteristics of Flatbush Diabetes
Patients present with very high blood sugars (>700mg/dl)
No antibodies as seen in type 1 Diabetes
Ketosis might be present
Obesity
family history of type2 diabetes
patients have signs of insulin resistance
Patients respond well to OHA ( oral hypoglycemic agents)
So far i have seen 3 pts of flatbush Diabetes.2 were siblings.Ketones in urine is the most confusing sign. They respond well to insulin and the way they respond rules out type 1 DM.Once we break down the glucotoxicity we are free to treat them with OADAs.
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