LATEST TREND - SEND OUT EXCESS SUGAR IN URINE!

New member of the squad against Diabetes!

Canagliflozin 

• Invokana
• Invokamet (Cangliflozin + Metformin)

Canagliflozin is a newest member in treatment of Type 2 Diabetes. This drug can be used as adjuvant to Diet & Exercise.

Canagliflozin inhibits Sodium Glucose Transport protein Sub type 2. This protein is responsible for reabsoption of sugar in the kidneys.

By stopping the activity of Sodium Glucose Transport Protein -2 (SGLT-2) will result in loss of glucose in urine. Canagliflozin can help lose about 80-120mg/dl sugar. Additional benefits are better control of Hypertension due to osmotic diuresis and weight loss. 

Half life of Canagliflozin is upto 12hours, Hence a twice daily dosage is preferred.

Canagliflozin comes in  the strengths of 50mg and 150mg

A recent welcome addition is introduction of Invokamet (Canagliflozin + Metformin)

The available combinations are 

Canagliflozin 50 mg + Metformin 500mg

Canagliglozin 50mg + Metformin 1000mg

Canagliflozin 150 mg + Metformin 500mg

Canagliglozin 150mg + Metformin 1000mg

Since most of our patients require twice daily metformin this combination will help give better sugar control. 1 Tablet with advantage of two drugs. 

This drug may help patients attain a better control of blood sugars.
Chances of hypoglycemia are relatively less

This Drug cannot be used in patients with Renal failure, Hypotension and Type 1 Diabetes!

Some patients ( ~5%) may experience the side effects like Female genital mycotic infections, Urinary tract infections and increased urination.

My previous write up about Canagliflozin - CLICK HERE!

This drug being marketed by Johnson & Johnson is expected to come to India soon.

More in news from Johnson & Johnson - JNJ

Dr.Riyaz Sheriff
R.S. Clinic

AFREZZA - DREAM COME TRUE?

Hi folks,

THE PAST!

Hope you all are doing well. After a break of 6 weeks from blogging I am back......!

So let’s start with good news!

There might be chance that out patients can use insulin without pricks!

Yes!


FDA has approved Oral insulin for clinical use. It’s named AFREZZA (uh-FREZZ-uh)

AFREZZA

AFREZZA is insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus.

AFREZZA is not for use in place of long-acting insulin. AFREZZA must be used with long-acting insulin in people who have type 1 diabetes mellitus.

 AFREZZA is not for use to treat diabetic ketoacidosis.

It is not known if AFREZZA is safe and effective for use in people who smoke. AFREZZA is not for use in people who smoke or have recently stopped smoking(less than 6 months)

It is not known if AFREZZA is safe and effective in children under 18 years of age

This drug comes in a form of inhaler with cartridges of 4units and 8 units.

This is how it looks!

We hope this product will be in India soon.

One main side effect is that it can reduce lung function. Some of them also have mentioned about incidences of lung cancer but these side effect profile needs to be confirmed. This drug will be ideal if the side effects mentioned are not because of AFREZZA.

Will update as soon as I get more info on this product.

Dr.Riyaz Sheriff
R.S Clinic
165/3B Teacher's colony
Vettuvankeni
Chennai 600115